Type:8 Tablets
Generic Name:Vonoprazan + Amoxicillin + Clarithromycin
Manufacturer:Ziska Pharmaceuticals Ltd.
Price:৳135.00
The standard triple therapy regimen is indicated in the eradication of H. pylori in active chronic gastritis, duodenal and gastric ulcers.
Helicobacter pylori (H. pylori) is implicated in the etiology of gastritis & peptic ulcer. The standard triple therapy regimen contains 20 mg vonoprazan tablet, 500 mg amoxicillin capsule and 500 mg clarithromycin tablet for oral administration is effective for eradicating H. pylori. Vonoprazan suppresses basal and stimulated gastric acid secretion at the secretory surface of the gastric parietal cell through inhibition of the H+ K+ -ATPase enzyme system in a potassium competitive manner. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, vonoprazan has been characterized as a type of gastric proton-pump inhibitor, in that it blocks the final step of acid production. Vonoprazan does not require activation by acid. Vonoprazan may selectively concentrate in the parietal cells in both the resting and stimulated states. Vonoprazan binds to the active proton pumps in a noncovalent and reversible manner. Amoxicillin is an antibacterial drug. Clarithromycin is a macrolide antimicrobial drug. Acid suppression enhances the replication of H. pylori bacteria and the stability and effectiveness of antimicrobials in the treatment of H. pylori infection.
