Rephaston 10

Rephaston 1010mg

Type:10 Tablets

Generic Name:Dydrogesterone

Manufacturer:Renata Limited

Price:300.00

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Indication

Endometriosis, Miscarriage, Menstrual disorders, Infertility, Dysmenorrhea, Dysfunctional uterine bleeding, Premenstrual syndrome, Hormone replacement therapy

Administration

May be taken with or without food.

Adult Dose

Oral Endometriosis Adult: 10 mg bid-tid cyclically or continuously. Recurrent miscarriage Adult: 10 mg bid given cyclically until conception, then continuously until wk 20 of pregnancy, after which dose may be gradually reduced. Menstrual disorders Adult: 10 mg bid in a cyclical regimen. Threatened miscarriage Adult: Initially, 40 mg followed by 10 mg or more every 8 hr, continued for a wk after symptoms are relieved. Reduce dose gradually after that unless symptoms return. Infertility Adult: 10 mg bid. Endometrial protection during menopausal hormonal replacement therapy Adult: 10 mg 1-2 times daily in a cyclical regimen or 5 mg daily.

Contraindication

Hypersensitivity; pregnancy. Undiagnosed abnormal vag bleeding, thromboembolic disorders, history or existing cerebrovascular or coronary artery disease, missed or incomplete abortion, known or suspected carcinoma of the breast or genital organs, severe hepatic dysfunction, as a diagnostic test for pregnancy.

Mode of Action

Dydrogesterone is a progestogen structurally related to progesterone. However, unlike progesterone, it does not induce an increase in temp nor inhibit ovulation and may be preferred over other progestational agents when contraceptive effect is not required. It does not have oestrogenic or androgenic properties.

Precaution

Monitor closely for loss of vision, proptosis, diplopia, migraine, signs and symptoms of embolic disorders. CVD or renal impairment, epilepsy, asthma, other conditions which may be aggravated by fluid retention. Lactation.

Side Effect

Dizziness, nausea, headache, fatigue, emotional lability, irritability; abdominal pain and distention; muskuloskeletal pain.

Interaction

Carbamazepine, griseofulvin, phenobarbital, rifampicin enhances the clearance of progestogens.

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