Sunicent

Sunicent50mg

Type:12 Capsules

Generic Name:Sunitinib

Manufacturer:Incepta Pharmaceuticals Ltd.

Price:12000.00

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Indication

Leukemia, Renal cell carcinoma, Gastrointestinal stromal tumor, Meningioma

Administration

May be taken with or without food.

Adult Dose

Hepatic Impairment Mild to moderate impairment: Dose adjustment not necessary for initial dose; monitor subsequent doses Severe impairment: Not studied

Child Dose

Safety and efficacy not established

Renal Dose

Renal Impairment No dose adjustment necessary

Contraindication

Hypersensitivity, Renal impairment

Mode of Action

Multikinase inhibitor (including VEGF & PDGF receptor tyrosine kinases) some of which are implicated in tumor growth, angiogenesis, and metastasis.

Precaution

CHF, HTN, history of QT interval prolongation, patients taking antiarrhythmics or w/ preexisting cardiac disease, bradycardia or electrolyte disturbances, hemorrhagic events, hypothyroidism. Perform CBC & physical exam. May affect ability to drive or operate machinery. Pregnancy.

Side Effect

>10% Dyspepsia (MRCC 46%),Altered taste (MRCC 43%; GIST 21%),Fatigue (GIST 42%; MRCC 74%),Diarrhea (GIST 40%; MRCC 55%),Rash (MRCC 38%; GIST 14%),Vomiting (MRCC 37%; GIST 24%),Constipation (MRCC 34%; GIST 20%),Skin discoloration (MRCC 33%; GIST 30%),Abdominal pain (GIST 33%; MRCC 20%),Nausea (GIST 31%; MRCC 54%),Anorexia (MRCC 31%; GIST 33%),Mucositis/stomatitis (GIST 29%; MRCC 53%),Dyspnea (MRCC 28%; GIST 10%),HTN (MRCC 28%; GIST 15%),Arthralgia (MRCC 28%; GIST 12%),Bleeding (MRCC 26%; GIST 18%),Headache (MRCC 25%; GIST 13%),Asthenia (GIST 22%),Lymphopenia (MRCC 21%),Fever (GIST 18%; MRCC 15%),Limb pain (MRCC 18%),Back pain (MRCC 17%; GIST 11%),Myalgia (MRCC 17%; GIST 14%),Cough (MRCC 17%; GIST 8%),Dry skin (17%),Hair color changes (17%),Neutropenia (MRCC 13%; GIST 11%),Alopecia (MRCC 12%),Hand-foot syndrome (MRCC 12%; GIST 14%),Dehydration (MRCC 11%) 1-10% Venous thrombotic events,Hemorrhoids,Pancreatitis,Flu-like syndrome <1% Hepatotoxicity,Acute renal failure,Adrenal dysfunction

Interaction

Increased plasma conc w/ strong CYP3A4 inhibitors (eg ketoconazole, ritonavir, itraconazole, erythromycin, clarithromycin, grapefruit juice). Decreased plasma conc w/ strong CYP3A4 inducers [eg rifampin, dexamethasone, phenytoin, carbamazepine, phenobarb, St. John's wort (Hypericum perforatum)]. Anticoagulants eg warfarin, acenocoumarol (periodically monitor platelets, prothrombin time/INR & physical exam).

Alternative brand of Sunicent

SutinibSutinib

  • 50mg
  • Capsule
  • Sunitinib

Price: ৳950.00

Drug International Ltd.

SunitixSunitix

  • 50mg
  • Capsule
  • Sunitinib

Price: ৳6270.00

Beacon Pharmaceuticals Ltd.