Widebac

Widebac50mg/vial

Type:1 combipack

Generic Name:Tigecycline

Manufacturer:Incepta Pharmaceuticals Ltd.

Price:600.00

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Indication

Complicated intra-abdominal infections; Complicated skin and skin structure infections, Community-acquired pneumonia

Administration

IV Preparation Reconstitute each vial with 5.3 mL NS or D5W to achieve a conc of 10 mg/mL IV Administration Infuse over 30-60 min

Adult Dose

The recommended daily dose is as follows: Adults: The recommended dosage regimen for Tigecycline is an initial dose of 100 mg, followed by 50 mg every 12 hours. Intravenous (IV) infusions of Tigecycline should be administered over approximately 30 to 60 minutes every 12 hours. The duration of therapy should be guided by the severity and site of the infection and the patient's clinical and bacteriological progress. The recommended duration of treatment with Tigecycline for complicated skin and skin structure infections or for complicated intra-abdominal infections is 5 to 14 days and for Community-acquired pneumonia is 7-14 days. Hepatic impairment: Mild to moderate: No dosage adjustment. Severe: 100 mg as a single dose, then 25 mg 12 hrly.

Child Dose

<18 years: Safety and efficacy not established

Renal Dose

Renal impairment: No dosage adjustment needed.

Contraindication

Hypersensitivity. Hospital-acquired pneumonia and ventilator-associated pneumonia. Use during tooth development.

Mode of Action

Tigecycline is a glycylcycline antibiotic which prevents protein synthesis of the susceptible bacteria by binding to its 30s ribosomal subunit. It is generally considered as bacteriostatic agent; w/ bactericidal activity against S. pneumonia and L. pneumophilia. Tigecycline antibacterial activity covers facultative gm+ve (including MRSA, vancomycin-susceptible Enterococcus faecalis) and gm-ve bacteria, and anaerobic bacteria.

Precaution

Hypersensitivity to tetracyclines. Use tigecycline in situations when alternative treatments are not suitable. Patients w/ complicated intra-abdominal infections secondary to clinically apparent intestinal perforation. Hepatic impairment. Pregnancy and lactation.

Side Effect

>10% Nausea (29.5%),Vomiting (19.7%),Diarrhea (12.7%) 1-10% Infection (8.3%),Fever (7.1%),Abd pain (6.8%),Headache (5.9%),HTN (4.9%),Anemia (4.2%),Dizziness (3.5%),Dyspnea (2.9%),Pruritus (2.6%),Rash (2.4%),Hypotension (2.3%),Insomnia (2.3%)

Interaction

Increased warfarin serum levels. May decrease efficacy of oral contraceptives.

Alternative brand of Widebac

TygacilTygacil

  • 50mg/Vial
  • Injection
  • Tigecycline

Price: ৳5000.00

Radiant Pharmaceuticals Ltd.