Retapex

Retapex1%

Type:15gm

Generic Name:Retapamulin 1% Topical

Manufacturer:Incepta Pharmaceuticals Ltd.

Price:300.00

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Indication

Impetigo, Bacterial skin infections

Adult Dose

Topical/Cutaneous Impetigo; Bacterial skin infections due to meticillin-susceptible, Staphylococcus aureus and Streptococcus pyogenes Adult: As 1% ointment: Apply onto affected area bid for 5 days. Re-evaluate if there is no response after 3 days of treatment. Total treatment area: <100 cm2 total body surface area.

Child Dose

Topical/Cutaneous Impetigo; Bacterial skin infections due to meticillin-susceptible, Staphylococcus aureus and Streptococcus pyogenes Child: As 1% ointment: >9 mth: Apply onto affected area bid for 5 days. Total treatment area: <2% of total body surface area.

Contraindication

Hypersensitivity.

Mode of Action

Retapamulin is a pleuromutilin antibacterial isolated from the fungus Clitopilus passeckerianus. It is a bacteriostatic agent that works by inhibiting biosynthesis of bacterial protein by binding at protein L3 on the ribosomal 50S subunit. It also inhibits peptidyl transfer and blocks P-site interactions at this site, thus preventing the formation of active 50S ribosomal subunits.

Precaution

Discontinue use if skin irritation occurs. Prolonged use may result in fungal or bacterial superinfection. Re-evaluate if there is no response within 3 days. Children <9 mth. Pregnancy, lactation. Lactation: use caution

Side Effect

1-10% Application site irritation (2%) Headache, pyrexia, pruritus, eczema, diarrhoea.

Interaction

Concurrent application w/ other topical products to the same skin area is not recommended.

Alternative brand of Retapex

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RetapexRetapex

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Incepta Pharmaceuticals Ltd.