Medicase - Recin - 10ml bot - 0.30% - Gentamicin 0.3% E/E prep

Recin0.30%

Type:10ml bot

Generic Name:Gentamicin 0.3% E/E prep

Manufacturer:Reman Drug Laboratories Ltd.

Price:৳35.00

Indication

Superficial ophthalmic infections, Otitis externa,

Adult Dose

Ophthalmic Superficial ophthalmic infections Adult: As eye drops: Instill 1-2 drops into affected eye up to 6 times daily. For severe infections, initially, 1-2 drops every 15 min, reducing the frequency gradually as the infection is controlled. As eye oint: Place a small amount into the conjunctival sac 2-3 times daily. Otic/Aural Otitis externa Adult: As ear drops: Instill 2-3 drops in the affected ear 3-4 times a day and at night.

Child Dose

Ophthalmic Superficial ophthalmic infections Child: As eye drops: Instill 1-2 drops into affected eye up to 6 times daily. For severe infections, initially, 1-2 drops every 15 min, reducing the frequency gradually as the infection is controlled. As eye oint: Place a small amount into the conjunctival sac 2-3 times daily. Otic/Aural Otitis externa Child: As ear drops: Instill 2-3 drops in the affected ear 3-4 times a day and at night.

Contraindication

History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum.

Mode of Action

Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.

Precaution

Concurrent use of neuromuscular blocking agents; myasthenia gravis, parkinsonism; conditions predisposing to ototoxicity and nephrotoxicity; lactation. Monitor plasma concentrations of gentamicin in patients receiving high doses or prolonged courses, in infants, elderly, patients with renal impairment, cystic fibrosis or significant obesity. Monitor auditory and renal functions. Lactation: safety in nursing infants unknown

Side Effect

Allergic contact dermatitis, Transient irritation, burning, stinging, Increased redness, lacrimation

Interaction

Additive effect w/ other neurotoxic and/or nephrotoxic drugs including cephalosporins, methicillin, amphotericin B, ciclosporin, cisplatin, potent diuretics (e.g. ethacrynic acid, furosemide) and neuromuscular blocking agents (e.g. succinylcholine, tubocurarine). May potentiate the effect of anticoagulants (e.g. warfarin, phenindione). May antagonise the effect of neostigmine and pyridostigmine. Increased risk of hypocalcaemia w/ bisphosphonates. Increased risk of neuromuscular blockade w/ botulinum toxin. Indometacin may increase the plasma concentration of gentamicin in neonates.