Type:Tablet
Generic Name:Meclizine Hydrochloride + Pyridoxine Hydrochloride
Manufacturer:Pharmasia Ltd.
Price:৳3.50
Nausea, vomiting, dizziness, motion sickness, radiation sickness and vertigo associated with diseases of vestibular motion sickness, radiation sickness and vertigo associated with diseases of vestibular system, morning sickness during pregnancy, drug induced nausea, vomiting induced by oral contraceptives or Estrogen preparations.
May be taken with or without food.
Oral Motion sickness Adult: 25-50 mg Meclizine 1 hr before travelling and repeat 24 hrly if needed. Vertigo and vestibular disorders Adult: 25-100 mg Meclizine daily in divided doses. Discontinue if there is no response after 1-2 wk of treatment. Radiation sickness: 50 mg Meclizine administered 2-12 hours prior to radiation treatment. Pyridoxine (vitamin B6) has been shown to be safe and effective in dosages of 50 to 200 mg per day.
Oral <12 years: Safety and efficacy not established
Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.
Meclozine blocks vasopressor response to histamine and has a slight blocking action against acetylcholine. It decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways. Pyridoxine is a water-soluble vitamin which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.
Prostate hypertrophy, obstruction of bladder neck, narrow angle glaucoma, pyloric stenosis. May impair ability to drive or operate machinery. Pregnancy. Lactation: Not known if excreted in milk; use caution
Drowsiness, thickening of bronchial secretions, dry mouth, fatigue, blurred vision.
Additive effects with CNS depressants, neuroleptics, anticholinergics, alcohol.
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