Cetrotide

Cetrotide0.25mg

Type:7's pack

Generic Name:Cetrorelix

Manufacturer:

Price:22958.95

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Indication

Assisted reproductive technologies, In-vitro fertilization

Adult Dose

Subcutaneous Assisted reproductive technologies Adult: As acetate: equiv to 0.25 mg cetrorelix either in the morning beginning on the day 5 or 6 of ovarian stimulation or in the evening beginning on day 5, and continued until ovulation induction.

Renal Dose

Severe renal impairment: Contraindicated

Contraindication

Hypersensitivity. Moderate to severe renal or hepatic impairment. Women with severe allergic conditions. Pregnancy and lactation;

Mode of Action

Cetrorelix, a synthetic decapeptide analog of naturally occurring gonadorelin, is a gonadorelin antagonist. It competitively blocks gonadorelin receptors on the anterior piyuitary gonadotroph and the subsequent transduction pathway, inducing a rapid, reversible suppression of gonadotrophin secretion.

Precaution

Women with active allergic conditions or a history of allergies; childn; elderly >65 yrs Lactation: Excretion in milk unknown/contraindicated

Side Effect

1-10% Ovarian hyperstimulation syndrome (4%),Nausea (1%),Hepatic enzyme elevation (1-2%),Headache (1%) <1% Erythema at injection site,Itching,Pruritus,Swelling,Redness,Hypotension,Rash,Cough

Pregnancy Category Note

Pregnancy Category: X Lactation: Excretion in milk unknown/contraindicated

Interaction

In vitro investigations have shown that interactions are unlikely with medications that are metabolised by cytochrome P-450 or glucuronised or conjugated in some other way. However, the possibility of interactions with commonly used medicinal products can not entirely be excluded.

Alternative brand of Cetrotide