Type:Tablet
Generic Name:Megestrol Acetate
Manufacturer:Drug International Ltd.
Price:৳35.00
Contraception, Breast carcinoma, Endometrial carcinoma, Anorexia and Cachexia
Should be taken with food.
Oral Palliative treatment of breast carcinoma Adult: 40 mg 4 times daily or 160 mg once daily. Palliative treatment of endometrial carcinoma Adult: 40-320 mg daily in divided doses. evaluate efficacy after 2 months of treatment; up to 800 mg/day may be used Anorexia and cachexia in patients with cancer or AIDS Adult: Initial: 800 mg daily. Usual range: 400-800 mg daily.
Renal impairment: Use with caution; in normal renal function, 57-78% is excreted in urine within 10 days
Pregnancy and lactation. Severe hepatic impairment.
Megestrol is a progestogen used as an antineplastic and appetite stimulant. The mechanism of it's antineoplastic effects is not known but may be due to inhibition of oestrogen synthesis, modulation of other steroid hormones and/or a direct cytotoxic effect on tumour cells.
History of thrombophlebitis, mild to moderate hepatic impairment, risk of fluid retention, history of depression, diabetes, hypertension, renal or cardiac dysfunction. Lactation: Not safe; do not nurse
Common Hypertension,Insomnia, mood swings Rash, sweating,Amenorrhea, breakthrough bleeding, change in menstrual flow, hot sweats, impotence, spotting Diarrhea, flatulence, indigestion, nausea, vomiting, weight gain Serious Deep vein thrombosis (DVT),Pulmonary embolism,Thrombophlebitis,Anemia,Adrenal insufficiency
Concentrations of indinavir may be reduced. Possible reduced efficacy of cisplatin. Warfarin half life may be increased. Megestrol concentration may be decreased by aminoglutethimide and enzyme-inducing drugs.
