Type:Tablet
Generic Name:Alprazolam
Manufacturer:Asiatic Laboratories Ltd.
Price:৳2.00
Oral Short-term management of anxiety Adult: 0.25-0.5 mg tid, increased to 3-4 mg daily if necessary. Elderly: Initially, 0.25 mg bid/tid. Panic attacks Adult Immediate-release 0.5 mg PO q8hr; may increase q3-4Days by ?1 mg/day Average dose: 5-6 mg/day PO May require up to 10 mg/day PO divided q8hr Extended-release 0.5-1 mg PO qDay; may increase q3-4Days by <1 mg/day Average dose: 3-6 mg PO qDay Anxiety Associated With Depression 1-4 mg/day PO divided q8hr Hepatic impairment: Avoid in severe impairment.
Potentiates action of alcohol and CNS depressants. Reduced conc with cigarette smoking by 50%. Potentially Fatal: Cimetidine and fluoxetine reduce the clearance of alprazolam. Alprazolam enhances activity of imipramine and desipramine.
Dosage reduction or gradual withdrawal. Dependence. Geriatric or debilitated patients. Muscle weakness, impaired hepatic or renal function; arteriosclerosis; obesity; depression particularly suicidal tendency; chronic pulmonary insufficiency. May impair ability to drive or operate machinery. Children <18 yr. Lactation: Enters breast milk/not recommended
Alprazolam has anxiolytic, muscle-relaxant, anticonvulsant, antidepressant and sleep-modifying effects. It binds to the ? aminobutyric acid (GABA)-specific sites throughout the CNS, leading to an increase in the inhibitory effect of GABA on neuronal excitability. Increased neuronal permeability to chloride ions thus results in hyperpolarisation and stabilisation.
<18 years old: Not recommended
Administration May be taken with or without food. Side effects eg sleepiness/drowsiness may be reduced if taken immediately after meals.
Anxiety disorders, Panic disorders, Nausea due to chemotherapy
Renal impairment: Use caution; not studied
>10% (4 mg dose) Drowsiness (41%),Depression (10-15%),Headache (10-15%),Constipation (10-15%),Diarrhea (10-15%),Dry mouth (10-15%) >10% (10 mg dose) Drowsiness (77%),Impaired coordination (40-50%),Increased appetite (30-35%),Fatigue (30-35%),Memory impairment (30-35%),Irritability (30-35%),Decreased salivation (30-35%),Cognitive disorders (20-30%),Insomnia (20-30%),Dcreased appetite (20-30%),Headache (20-30%),Lightheadedness (20-30%),Dysarthria (20-30%),Diarrhea, constipation, and nausea/vomiting (20-30%),Weight change (20-30%),Nasal congestion (15-20%),Decreased or increased libido (10-15%),Menstrual disorder (10-15%),Difficult micturition (10-15%) 1-10% (4 mg dose) Tachycardia (5-10%),Confusion (5-10%),Insomnia (5-10%),Nausea/vomiting (5-10%),Blurred vision (5-10%),Nasal congestion (5-10%),Hypotension (1-5%),Syncope (1-5%),Akathisia (1-5%),Dizziness (1-5%),Increased salivation (1-5%),Nervousness (1-5%),Tremor (1-5%),Weight change (1-5%) 1-10% (10 mg dose) Increased salivation (5-10%),Talkativeness (1-5%),Incontinence (1-5%) Potentially Fatal: Blood dyscrasias.
Acute narrow-angle glaucoma, preexisting CNS depression or coma, resp depression, acute pulmonary insufficiency or sleep apnoea; severe hepatic impairment; pregnancy, lactation.
