A Rox

A Rox300mg

Type:Tablet

Generic Name:Roxithromycin

Manufacturer:Ambee Pharmaceuticals Ltd.

Price:11.04

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Indication

Pneumonia, Pharyngitis, Susceptible infections, Sinusitis, Otitis media, Cellulitis,Tonsillitis, Folliculitis, Carbuncles, Prostatitis, Urethritis, Acute and chronic bronchitis, Bronchopneumonia, Furuncles, Pyoderma, Impetigo and infected dermatitis, Cervicitis and salpingitis

Administration

Should be taken on an empty stomach. Take at least 15 min before meals.

Adult Dose

Oral Susceptible infections Adult: 150 mg bid or 300 mg once daily for 5-10 days in susceptible infections. Hepatic impairment: Usual daily doses should be halved in hepatic impairment.

Child Dose

Oral Susceptible infections Child: 6-40 kg: 5-8 mg/kg daily.

Renal Dose

Renal impairment: Dosage adjustment may be required.

Contraindication

Hypersensitivity. Porphyria.

Mode of Action

Roxithromycin inhibits protein synthesis by irreversibly binding to the 50s ribosomal subunits thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.

Precaution

Hepatic impairment. Monitor liver function. Prolonged treatment increases risk of hepatotoxicity. History of arrhythmias.

Side Effect

Nausea, vomiting, abdominal pain, diarrhoea, weakness, malaise, anorexia, constipation, dyspepsia, flatulence; hepatitis; rashes, headache, dizziness, weakness, changes in blood counts; increased liver enzyme values; eosinophilia; rarely, acute pancreatitis.

Interaction

May raise serum levels of ciclosporin and digoxin. Increased risk of rhabdomyolysis when used with simvastatin.

Alternative brand of A Rox

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