Type:Tablet
Generic Name:Zafirlukast
Manufacturer:Beximco Pharmaceuticals Ltd.
Price:৳26.00
Chronic asthma
Should be taken on an empty stomach. Take at least 1 hr before or 2 hr after meals.
Oral Chronic asthma Adult: 20 mg bid. Hepatic impairment: Contraindicated.
Oral Chronic asthma Child: 5-11 yr: 10 mg bid. >12 yr: 20 mg bid.
Renal Impairment Dose adjustment not necessary
Hypersensitivity, hepatic impairment, cirrhosis, acute asthmatic attacks. Lactation.
Zafirlukast selectively antagonises the leukotriene D4 receptor. It inhibits bronchoconstriction caused by various inhaled antigens or irritants. It is not used in acute asthma attacks.
Not indicated for use in the reversal of bronchospasm in acute asthma attacks. Avoid abrupt substitution to oral or inhaled corticosteroids. Renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor for improvements in air flow; monitor closely for sign/symptoms of hepatic injury; periodic monitoring of LFTs. Lactation: Excreted in breast milk; not recommended
>10% headache (12.9% in age >12 yr) 1-10% Abdominal pain (1.8%),Infection (3.5%),Nausea (3.1%),Diarrhea (2.8%),Generalized pain (1.8%),Vomiting (1.5%),Dyspepsia/gastritits (1.3%),Increased ALT (1.5%),Infection (4%),Back pain (2%),Weakness (2%),Myalgia (2%) Frequency Not Defined Eosinophilia Eosinophilic pneumonia Vasculitis Malaise Bleeding Bruising Potentially Fatal: Severe hepatotoxicity.
May enhance anticoagulant activity of warfarin resulting to increased prothrombin time. Decreased plasma levels w/ theophylline, terfenadine and erythromycin. Increased plasma levels w/ fluconazole and high dose aspirin.