Xelitor

Xelitor10mg

Type:Tablet

Generic Name:Atorvastatin

Manufacturer:Novo Healthcare and Pharma Ltd.

Price:8.00

Ad

Indication

Oral Mixed dyslipidaemia, Heterozygous familial hypercholesterolaemia, Nonfamilial hypercholesterolaemia Adult: Initially, 10 or 20 mg once daily, may be adjusted at 4-wk interval. May initiate 40 mg once daily in patients who require >45% reduction in LDL-cholesterol. Max: 80 mg/day. Elderly: No dosage adjustment needed.

Administration

May increase risk of myopathy and rhabdomyolysis w/ CYP3A4 potent inhibitor (e.g. HIV or HCV protease inhibitors, itraconazole, clarithromycin), fenofibrate, colchicines, fixed combination of lopinavir/ritonavir. May decrease plasma concentration w/ CYP3A4 inducer (e.g. rifampicin, efavirenz). May significantly increase AUC and peak plasma concentration of digoxin. Increased AUC for norethindrone and ethinyl estradiol. Potentially Fatal: Increased risk of myopathy or rhabdomyolysis w/ ciclosporin, gemfibrozil, telaprevir, tipranavir.

Adult Dose

Patients who consume substantial quantities of alcohol. History of liver disease. Patients with risk factors for myopathy or rhabdomyolysis. Hypothyroidism should be properly managed prior to starting statin therapy. Children <10 yr. Premenarcheal females. Lactation: Because of the potential for adverse reactions in nursing infants, women taking this drug should not breastfeed; contraindicated in nursing mothers.

Renal Dose

Atorvastatin competitively inhibits HMG-CoA reductase, the enzyme that catalyses the conversion of HMG-CoA to mevalonate. This results in the induction of the LDL receptors and stimulation of LDL catabolism, leading to lowered LDL-cholesterol levels.

Contraindication

Oral Mixed dyslipidaemia, Heterozygous familial hypercholesterolaemia, Nonfamilial hypercholesterolaemia Child: Heterozygous familial hypercholesterolaemia: 10-17 yr 10 mg once daily, may increase at intervals of at least 4 wk to max 20 mg/day.

Mode of Action

Atorvastatin can be administered as a single dose at any time of the day, with or without food. Avoid excessive consumption (>1 L/day) of grapefruit juice.

Precaution

Primary hypercholesterolemia (heterozygous familial and nonfamilial), Mixed Dyslipidemia, Homozygous familial hypercholesterolemia, Hypertriglyceridemia, Familial hypercholesterolemia, Cardiovascular event prevention, Primary dysbetalipoproteinemia

Side Effect

Renal Insufficiency: Renal disease does not affect the plasma concentrations or LDL-C reduction of atorvastatin; thus, dosage adjustment in patients with renal dysfunction is not necessary.

Pregnancy Category Note

>10% Diarrhea (5-14%),Nasopharyngitis (4-13%),Arthralgia (4-12%) 1-10% Insomnia (1-5%),Urinary tract infection (4-8%),Nausea (4-7%),Dyspepsia (3-6%),Increased transaminases (2-3%),Muscle spasms (2-5%),Musculoskeletal pain (2-5%),Myalgia (3-8%),Limb pain (3-8%),Pharyngolaryngeal pain (1-4%) Frequency Not Defined Angina,Syncope,Dyspnea,Myopathy,Anaphylaxis,Stevens-Johnson syndrome,Myositis Potentially Fatal: Thrombocytopenia. Rhabdomyolysis with acute renal failure.

Interaction

Hypersensitivity, active liver disease or unexplained persistent elevations of serum transaminase, porphyria, pregnancy, lactation.

Alternative brand of Xelitor

Lipicon 20Lipicon 20

  • 20mg
  • Tablet
  • Atorvastatin

Price: ৳200.00

Eskayef Pharmaceuticals Ltd.

Lipicon 10Lipicon 10

  • 10mg
  • Tablet
  • Atorvastatin

Price: ৳120.00

Eskayef Pharmaceuticals Ltd.

Lipicon 40Lipicon 40

  • 40mg
  • Tablet
  • Atorvastatin

Price: ৳24.00

Eskayef Pharmaceuticals Ltd.

TCL-R 10TCL-R 10

  • 10mg
  • Tablet
  • Atorvastatin

Price: ৳120.00

Aristopharma Limited

Xelpid 10Xelpid 10

  • 10mg
  • Tablet
  • Atorvastatin

Price: ৳100.00

Healthcare Pharmaceuticals Ltd.

Aztor 10Aztor 10

  • 10mg
  • Tablet
  • Atorvastatin

Price: ৳116.00

Sun Pharmaceutical (Bangladesh) Ltd.

Avas 40Avas 40

  • 40mg
  • Tablet
  • Atorvastatin

Price: ৳388.00

Opsonin Pharma Limited

Astatin 10Astatin 10

  • 10mg
  • Tablet
  • Atorvastatin

Price: ৳10.01

United Chemicals & Pharmaceuticals Ltd.

Tigilo 20Tigilo 20

  • 20mg
  • Tablet
  • Atorvastatin

Price: ৳200.60

Labaid Pharmaceuticals Ltd.

Aztor 40Aztor 40

  • 40mg
  • Tablet
  • Atorvastatin

Price: ৳260.00

Sun Pharmaceutical (Bangladesh) Ltd.

Stacor 20Stacor 20

  • 20mg
  • Tablet
  • Atorvastatin

Price: ৳200.00

Unimed Unihealth Pharmaceuticals Ltd.

Atostin 10Atostin 10

  • 10mg
  • Tablet
  • Atorvastatin

Price: ৳10.00

Somatec Pharmaceuticals Ltd.

LivasLivas

  • 10mg
  • Tablet
  • Atorvastatin

Price: ৳10.00

EDCL

Aster 20Aster 20

  • 20mg
  • Tablet
  • Atorvastatin

Price: ৳150.00

Euro Pharma Ltd.

LipilesLipiles

  • 20mg
  • Tablet
  • Atorvastatin

Price: ৳18.00

Pharmasia Ltd.

Atasin 10Atasin 10

  • 10mg
  • Tablet
  • Atorvastatin

Price: ৳110.00

ACI Limited

AtoconAtocon

  • 10mg
  • Tablet
  • Atorvastatin

Price: ৳0.00

Medicon Pharmaceuticals Ltd.

Divastin 20Divastin 20

  • 20mg
  • Tablet
  • Atorvastatin

Price: ৳253.40

Drug International Ltd.

Lipostat 10Lipostat 10

  • 10mg
  • Tablet
  • Atorvastatin

Price: ৳100.30

Navana Pharmaceuticals Ltd.

TCL-R 20TCL-R 20

  • 20mg
  • Tablet
  • Atorvastatin

Price: ৳200.00

Aristopharma Limited