Trilix

Trilix1.5mg

Type:Tablet

Generic Name:Indapamide

Manufacturer:Silva Pharmaceuticals Ltd.

Price:5.00

Ad

Indication

Hypertension, Congestive heart failure

Administration

Should be taken with food.

Adult Dose

Oral Hypertension Adult: 1.25-2.5 mg once daily, alone or in conjunction with other antihypertensives. Oedema Adult: 2.5 mg once daily increased to 5 mg daily after 1 wk if needed.

Child Dose

Safety & efficacy not established

Contraindication

Anuria, severe hepatic impairment.

Mode of Action

Indapamide enhances excretion of sodium, chloride and water by interfering with the transport of sodium ions across the renal tubular epithelium.

Precaution

Pregnancy, lactation, elderly, renal impairment, fluid or electrolyte imbalance, hyperuricaemia, DM, lupus erythematosus. Lactation: not known if excreted into breast milk, avoid

Side Effect

1-10% Hypotension,Palpation,Flushing,Dizziness,Lightheadedness,Vertigo,Headache,Weakness,Restlessness,Drowsiness,Fatigue,Lethargy,Malaise,Anorexia,Nausea/vomiting,Nocturia,Polyuria,Blurred vision,Rhinnorhea,Electrolyte abnormalities,Pruritus,Rash <1% Cutaneous vasculitis,Glycosuria,Pancreatitis

Interaction

Additive effect with other antihypertensive agents and diuretics. Increased chance of hypokalaemia with corticosteroids, corticotropin and amphotericin. Potentially Fatal: Increased risk of lithium toxicity. Hypokalaemia enhances digitalis toxicity with cardiac gycosides.

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