Roxyzin

Roxyzin10mg/5ml

Type:100ml bot

Generic Name:Hydroxyzine Hydrochloride

Manufacturer:Incepta Pharmaceuticals Ltd.

Price:40.00

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Indication

Pruritus, Allergic conditions, Generalized anxiety disorder, Psychoneurosis, Chronic urticaria, Atopic or contact dermatoses, Pre- or post-operative sedation

Administration

May be taken with or without food.

Adult Dose

Oral For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested: Adult: 50-100 mg 4 times daily. For use in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus: Adult: Initially, 25 mg at night increased if required up to 25 mg 3-4 times daily. As a sedative when used as a premedication and following general anesthesia: Adult: 50-100 mg. Hepatic impairment: Reduce total daily dose by 33%.

Child Dose

Oral For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested Children under 6 years: 50 mg daily in divided doses >6 years: 50 to 100 mg daily in divided doses. For use in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus Child: 6 mth to 6 yr Initially, 5-15 mg/day, increased to 50 mg/day in divided doses; >6 yr Initially, 15-25 mg/day, increased up to 50-100 mg/day in divided doses. As a sedative when used as a premedication and following general anesthesia Child: 0.6 mg/kg. Hepatic impairment: Reduce total daily dose by 33%. For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested,children under 6 years, 50 mg daily in divided doses and over 6 years, 50 to 100 mg daily in divided doses. For use in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus, children under 6 years, 50 mg daily in divided doses and over 6 years, 50 to 100 mg daily in divided doses. As a sedative when used as a premedication and following general anesthesia, 0.6 mg/kg in children.

Renal Dose

Renal Impairment >50 mL/min: Dose adjustment not necessary <50 mL/min: Administer 50% normal dose

Contraindication

Porphyria, neonates, pregnancy, lactation.

Mode of Action

Hydroxyzine, a piperazine derivative, blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and resp tract. It is a sedating antihistamine w/ antimuscarinic and significant sedative properties. It also possesses skeletal muscle relaxing, bronchodilator, antiemetic and analgesic properties.

Precaution

Renal and hepatic impairment; narrow-angle glaucoma; epilepsy; prostatic hypertrophy; bladder neck obstruction; asthma; COPD. May impair ability to drive or operate machinery. Lactation: Excretion in milk unknown; use with caution

Side Effect

Dizziness, ataxia, fatigue, drowsiness, hallucination, seizure, dry mouth, nervousness, xerostomia, involuntary movements, slurred speech, headache, paraesthesia, tremor, blurred vision, resp depression, pruritus, rash, urticaria, allergic reaction.

Interaction

Additive or may potentiate CNS depressant effects of opiates or other analgesics, barbiturates or other sedatives, and anaesth. MAOIs and TCAs potentiate antimuscarinic effects.

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