Type:8 Tablets
Generic Name:Alendronic Acid + Vitamin D3
Manufacturer:Square Pharmaceuticals PLC.
Price:৳241.60
Treatment of osteoporosis in postmenopausal women: One tablet once weekly. Treatment to increase bonemass in men with osteoporosis: One tablet once weekly. Hepatic Impairment No dosage adjustment needed.
Concomitant iron, calcium supplements and antacids hinder alendronate absorption. Concomitant aspirin or NSAIDs may increase the incidence of adverse GI effects.
Upper GI disorders (discontinue if symptoms worsen); history of ulcers, active GI bleeding. Correct vitamin D and calcium deficiency before starting therapy. To be taken half an hr before breakfast and remain upright for at least 30 minutes after admin. Not recommended for use in patients with CrCl <35 ml/min.
Alendronic acid reduces bone resorption by inhibiting the action of osteoclasts.
Osteopetrosis, postmenopausal osteoporosis, Paget's disease of bone
Dosing in elderly and renal insufficiency: No dosage adjustment is necessary for the elderly or for patients with mild-to-moderate renal insufficiency (creatinine clearance 35 to 60 mL/min). CrCl (ml/min) <35 Not recommended.
The most common side-effect is digestive reactions. These reactions include irritation, inflammation, or ulcers of the esophagus, which may sometimes bleed. This may occur especially if patients do not drink a full glass of water or if they lie down in less than 30 minutes or before their first food of the day. Less common side-effects are nausea, vomiting, a full or bloated feeling in the stomach, constipation, diarrhea, black or bloody stools, gas, headache, a changed sense of taste, and bone, muscle, or joint pain.
Hypocalcaemia; oesophageal abnormalities and factors which delay oesophageal emptying; severe renal impairment; hypersensitivity; inability to stand or sit upright for <30 min. Pregnancy, lactation.
