Type:1 amps
Generic Name:Dopamine Hydrochloride
Manufacturer:Incepta Pharmaceuticals Ltd.
Price:৳45.00
Shock, Acute heart failure, Hypotension
Hemodynamic Conditions Treatment of hypotension, low cardiac output, poor perfusion of vital organs; used to increase mean arterial pressure in septic shock patients who remain hypotensive after adequate volume expansion 1-5 mcg/kg/min IV (low dose): May increase urine output and renal blood flow 5-15 mcg/kg/min IV (medium dose): May increase renal blood flow, cardiac output, heart rate, and cardiac contractitlity 20-50 mcg/kg/min IV (high dose): May increase blood pressure and stimulate vasoconstriction; may not have a beneficial effect in blood pressure; may increase risk of tachyarrhythmias May increase infusion by 1-4 mcg/kg/min at 10-30 min intervals until optimum response obtained Titrate to desired response
Hemodynamic Conditions Treatment of hypotension 1-5 mcg/kg/min IV, increased to 5-20 mcg/kg/min; not to exceed 50 mcg/kg/min Titrate to desired response
Pheochromocytoma, uncorrected tachyarrhythmias, ventricular fibrillation. Hypersensitivity.
Dopamine stimulates dopaminergic receptors at lower doses producing renal and mesenteric vasodilation while at higher doses stimulate both dopaminergic and ?-adrenergic receptors producing cardiac stimulation and renal vasodilation. It increases heart rate and force of contraction. At low infusion rates vasodilatation occurs in the renal, mesenteric, coronary and cerebral beds. At higher rates vasoconstriction in skeletal muscles and a rise in BP.
Shock secondary to MI, history of peripheral vascular disease. Correct hypovolaemia before infusion. History of occlusive vascular disease e.g, atherosclerosis, Raynaud's disease, Buerger's disease, diabetic endarteritis; disproportionate increase in diastolic pressure. Pregnancy. Lactation: Unknown whether drug is excreted into breast milk; use caution
Cardiovascular: Ventricular arrhythmia, atrial fibrillation (at very high doses), ectopic beats, tachycardia, anginal pain, palpitation, cardiac conduction abnormalities, widened QRS complex, bradycardia, hypotension, hypertension, vasoconstriction Respiratory: Dyspnea Gastrointestinal: Nausea, vomiting Metabolic/nutritional: Azotemia Central nervous system: Headache, anxiety Endocrine: Piloerection Ocular: Increased intraocular pressure; dilated pupils Gangrene of extremities has occurred when high doses were administered for prolonged periods or in patients with occlusive vascular disease receiving low doses of dopamine hydrochloride
Pregnancy category: C Lactation: Unknown whether drug is excreted into breast milk; use caution
Cyclopropane and halogenated hydrocarbon anaesthetics may sensitise myocardium to dopamine and precipitate ventricular arrhythmias. MAO inhibitors prolong and increase dopamine effects. Ergots potentiate vasoconstriction action of dopamine. Alpha-blockers unmask dopamine's beta action.
