Type:Tablet
Generic Name:Lomefloxacin
Manufacturer:Square Pharmaceuticals PLC.
Price:৳15.10
Chronic bronchitis, Otitis media, Bacterial Conjunctivitis, Urinary tract infections, Surgical Prophylaxis, Otitis externa
May be taken with or without food.
Oral Acute bacterial exacerbation of chronic bronchitis Adult: 400 mg once daily for 10 days. Uncomplicated urinary tract infections Adult: 400 mg once daily. Due to E. coli: For 3 successive days. Due to K. pneumoniae, P. mirabilis or S. saprophyticus: For 10 successive days. Complicated urinary tract infections Adult: Due to E. coli, K. pneumoniae, P. mirabilis or P. aeruginosa: 400 mg once daily for 14 successive days. Prophylaxis of surgical infections Adult: 400 mg as a single dose 1-6 hr before procedure.
Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily. CrCl (ml/min) Dosage Recommendation 10-40 Initially, 400 mg daily. Maintenance: 200 mg daily.
Hypersensitivity to the drug or other quinolones; children <18 yr; pregnancy and lactation.
Lomefloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in reproduction of bacterial DNA.
Avoid prolonged exposure to sunlight or artificial UV light. Known or suspected CNS disorders e.g. severe cerebral arteriosclerosis, epilepsy or other factors that predispose to seizures. Avoid in patients with known QT prolongation, uncorrected hypokalaemia. May impair ability to drive or operate machinery. Renal impairment.
Nausea, abdominal pain or discomfort, diarrhoea; headache, dizziness, insomnia; rash, pruritus, photosensitivity; thrombocytopenia. Potentially Fatal: Anaphylactic or anaphylactoid reactions.
Reduced bioavailability with sucralfate, antacids containing magnesium or aluminium, vitamin or mineral supplements containing iron. Increased serum levels with cimetidine. Potential increase in serum levels of ciclosporin. Renal elimination reduced with probenecid. Potentially Fatal: Increased risk of ventricular arrhythmias with class IA (quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmic agents.
