Mexlo 400

Mexlo 400400mg

Type:Tablet

Generic Name:Lomefloxacin

Manufacturer:Square Pharmaceuticals PLC.

Price:15.10

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Indication

Chronic bronchitis, Otitis media, Bacterial Conjunctivitis, Urinary tract infections, Surgical Prophylaxis, Otitis externa

Administration

May be taken with or without food.

Adult Dose

Oral Acute bacterial exacerbation of chronic bronchitis Adult: 400 mg once daily for 10 days. Uncomplicated urinary tract infections Adult: 400 mg once daily. Due to E. coli: For 3 successive days. Due to K. pneumoniae, P. mirabilis or S. saprophyticus: For 10 successive days. Complicated urinary tract infections Adult: Due to E. coli, K. pneumoniae, P. mirabilis or P. aeruginosa: 400 mg once daily for 14 successive days. Prophylaxis of surgical infections Adult: 400 mg as a single dose 1-6 hr before procedure.

Renal Dose

Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily. CrCl (ml/min) Dosage Recommendation 10-40 Initially, 400 mg daily. Maintenance: 200 mg daily.

Contraindication

Hypersensitivity to the drug or other quinolones; children <18 yr; pregnancy and lactation.

Mode of Action

Lomefloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in reproduction of bacterial DNA.

Precaution

Avoid prolonged exposure to sunlight or artificial UV light. Known or suspected CNS disorders e.g. severe cerebral arteriosclerosis, epilepsy or other factors that predispose to seizures. Avoid in patients with known QT prolongation, uncorrected hypokalaemia. May impair ability to drive or operate machinery. Renal impairment.

Side Effect

Nausea, abdominal pain or discomfort, diarrhoea; headache, dizziness, insomnia; rash, pruritus, photosensitivity; thrombocytopenia. Potentially Fatal: Anaphylactic or anaphylactoid reactions.

Interaction

Reduced bioavailability with sucralfate, antacids containing magnesium or aluminium, vitamin or mineral supplements containing iron. Increased serum levels with cimetidine. Potential increase in serum levels of ciclosporin. Renal elimination reduced with probenecid. Potentially Fatal: Increased risk of ventricular arrhythmias with class IA (quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmic agents.

Alternative brand of Mexlo 400

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