Lucrin Depot

Lucrin Depot11.25mg

Type:Injection

Generic Name:Leuprolide acetate

Manufacturer:

Price:37.00

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Indication

Uterine fibroids, Endometriosis, Prostate cancer

Adult Dose

Advanced Prostate Cancer Recommended Dose: 1 mg (0.2 mL) administered as a single daily SC injection. Endometriosis 3.75 mg IM monthly for up to 6 months or 11.25 mg IM every 3 months for 2 doses (6 months total) Recommended duration of treatment is 6 months; may treat again for additional 6 months, but with concomitant administration of norethindrone Uterine Leiomyomata (Fibroids) 3.75 mg IM monthly for up to 3 months or 11.25 mg IM once Use concomitant iron treatment

Child Dose

Central Precocious Puberty Indicated when signs of sexual maturity begin to develop in girls <8 years old and boys <9 years old; may be discontinued at appropriate age of onset of puberty (eg, 11 years in females and 12 years in males), at physician's discretion 50 mcg/kg/day SC; may be titrated upward by 10 mcg/kg/day if downregulation not achieved <2 years old: Safety and efficacy not established

Contraindication

Pregnancy, lactation; hypersensitivity to GnRH, GnRH agonist analogs or product excipients; undiagnosed abnormal vaginal bleeding.

Mode of Action

Leuprorelin is a gonadotropin-releasing hormone (GnRH) analogue. Following an initial stimulation of gonadotrophins, continuous admin of Leuprorelin leads to down regulation of GnRH receptors and subsequently reduces pituitary gonadotrophin secretion. Reduced gonadotrophin levels lead to inhibition of sex hormone (testosterone and oestrogen) production. Within 2-4 wk after treatment initiation, testosterone levels in male may be reduced to below castrate threshold.

Precaution

Vary inj site periodically. May cause transient elevation of testosterone levels during the first 1-2 wk, which may lead to worsening or onset of new symptoms (e.g. bone pain, neuropathy, haematuria) in prostate cancer patients. Ureteral obstruction and spinal cord compression have been reported; closely monitor patients with urinary obstruction and/or metastatic vertebral lesion. Leuprorelin is associated with increased risk of diabetes and certain CV diseases (heart attack, sudden cardiac death, stroke) when used in men for treatment of prostate cancer. For prostate cancer, monitor response by testosterone and prostate-specific antigen (PSA) levels. For precocious puberty in children, monitor response by GnRH stimulation test sex steroid levels 1-2 month after treatment initiation. Leuprorelin usually inhibits ovulation and stops menstruation in women, but does not incur contraception, non-hormonal contraception should be used as pregnancy is contraindicated. May cause adverse reactions associated with hypoestrogenism and loss in bone density. Lactation: Contraindicated; not known if drug is excreted in breast milk; make decision to either discontinue nursing or discontinue drug, taking into account risk and benefits to the mother

Side Effect

>10% Hot flashes (57%),Cardiovascular changes or ischemia (19%),Fatigue (18%),Pain (13%),Peripheral edema (12%) 1-10% Asthenia (10%),Gynocomastia (7%),Headache (7%),Testicular atrophy (7%),Anorexia (6%),Anemia (5%),Bone pain (5%),Constipation (7%),Urinary frequency (6%),Dermatitis (5%),Dizziness (5%),Nausea and vomiting (5%),Gastroenteritis (3%),Myalgia (3%),UTI (3%),Dyspnea (2%) Frequency Not Defined Convulsion,Depression,Neuropathy,Decreased bone density,Hematuria,Obstruction of ureter or bladder,Impotence,Sweating,Implant site reactions (pain, bruising, edema),Spinal cord compression (rare)

Alternative brand of Lucrin Depot

Lucrin DepotLucrin Depot

  • 3.75mg
  • Injection
  • Leuprolide acetate

Price: ৳17.00