Type:Capsule
Generic Name:Fluvastatin
Manufacturer:Opsonin Pharma Limited
Price:৳20.14
Hyperlipidaemias, Hypercholesterolemia
May be taken with or without food.
Oral Hypercholesterolemia & Mixed Dyslipidemia Adult: Initially, 20-40 mg once daily in the evening, may increase at intervals of 4 wk to max 80 mg/day in 12hrly divided dose. Hepatic Impairment Contraindicated in active liver disease or unexplained transaminase elevations
Oral Hyperlipidaemias Child: Heterozygous familial hypercholesterolaemia: 10-16 yr 20 mg once daily. If necessary, may increase dose at 6-wkly intervals to 40 mg bid or 80 mg once daily as modified-release.
Renal Impairment CrCl <30 mL/min: Adjust dose amount; not to exceed 40 mg/day
Acute liver disease; unexplained persistently raised serum aminotransferase concentrations; porphyria; pregnancy; lactation.
Fluvastatin acts by competitively inhibiting HMG-CoA reductase, the enzyme for cholesterol synthesis. It reduces total cholesterol, triglycerides, LDL and VLDL concentrations in plasma. It also increases HDL concentrations.
History of liver disease; high alcohol intake. Manage hypothyroidism adequately before starting treatment. Report unexplained muscle pain. Monitor LFTs. Discontinue in case of marked or persistent increase in serum aminotransferase or creatine phosphokinase. Severe renal impairment. Lactation: enters breast milk; contraindicated
1-10% Headache (9%),Dyspepsia (8%),Abdominal pain (5%),Diarrhea (5%),Myalgia (5%),Fatigue (3%),Insomnia (3%),Nausea (3%),Sinusitis (3%),Bronchitis (2%),UTI (2%),Transaminases increased (1.1%) <1% Rash,Back pain,Arthralgia,Myopathy,Rhabdomyolysis,Rupture of tendon,CPK increased,Pharyngitis,Rhinitis,Cough,Constipation,Pancreatitis,Dizziness
Pregnancy Category: X Lactation: enters breast milk; contraindicated
Bleeding and increased prothrombin time w/ coumarin anticoagulants. May increase the risk of myopathy and rhabdomyolysis w/ HIV protease inhibitors, colchicine, bezafibrate, ciprofibrate or niacin (nicotinic acid), ciclosporin and fluconazole. Reduced bioavailability w/ concomitant rifampicin.
