Type:Tablet
Generic Name:Lacidipine
Manufacturer:Incepta Pharmaceuticals Ltd.
Price:৳4.00
Hypertension, Storke prevention
May be taken with or without food.
Oral Hypertension Adult: Initially, 2 mg once daily, may increase after 3-4 wk to 4 mg/day. Max: 6 mg/day. Hepatic impairment: Severe: Reduce dose.
Within 1 mth of MI, cardiogenic shock, unstable angina, aortic stenosis.
Lacidipine is a potent dihydropyridine Ca antagonist mainly selective for Ca channels in the vascular smooth muscle. It dilates peripheral arterioles resulting in reduced peripheral vascular resistance and BP.
Conduction abnormalities, congenital or acquired QT prolongation, poor cardiac reserve. Hepatic impairment. Pregnancy and lactation.
Headache, flushing, oedema, dizziness, palpitations, aggravation of angina, increased alkaline phosphatase. Rarely asthenia, rash (e.g. erythema and itching), gastric upset, nausea, gum hyperplasia, polyuria, muscle cramps, mood disturbances.
Additive effect w/ diuretics, ACE inhibitors and beta-blockers. May increase plasma level w/ cimetidine. Metabolism may be affected by CYP3A4 inhibitors (e.g. itraconazole) and inducers (e.g. rifampicin). May attenuate antihypertensive effect w/ corticoids or tetracosactid
