Type:IV Injection
Generic Name:Cefpirome
Manufacturer:Square Pharmaceuticals PLC.
Price:৳402.72
Susceptible infections
IV Administration Administer by IV inj over 3-5 min, OR By intermittent infusion over 20-30 min
Intravenous Susceptible infections Adult: As sulfate: 1-2 g every 12 hrly
Renal impairment: Loading dose: 1-2 g followed by a maintenance dose adjusted according to CrCl. CrCl (ml/min) 20-50 0.5-1 g bid. 5-20 0.5-1 g once daily. <5 (in haemodialysis patients) 0.5 or 1 g once daily with half-dose after each dialysis session.
Hypersensitivity; porphyria.
Cefpirome binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Allergy to penicillin or to cephalosporins; renal impairment, monitor renal and haematological status; pregnancy and lactation. Lactation: excreted in breast milk; unsure if safe; do not use
<1% Colitis,Diarrhea,Dyspnea,Headache,Phlebitis,Rash,Vaginitis,Vomiting Potentially Fatal: Pseudomembranous colitis.
Reduced clearance with probenecid.