Doxiderm

Doxiderm50mg/1g

Type:30gm tube

Generic Name:Doxepin 5% Topical

Manufacturer:Incepta Pharmaceuticals Ltd.

Price:120.00

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Indication

Pruritus, Chronic idiopathic urticaria (hives), Atopic dermatitis, lichen simplex chronicus

Adult Dose

Adult: apply thinly 3-4 times daily; usual max. 3 g per application; usual total max. 12 g daily; coverage should be less than 10% of body surface area. Use in Elderly Patients: Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range.

Child Dose

Child over 12 years: apply thinly 3-4 times daily; usual max. 3 g per application; usual total max. 12 g daily; coverage should be less than 10% of body surface area. The use of Doxepin cream in pediatric patients is not recommended.

Contraindication

Patients with untreated narrow angle glaucoma or a tendency to urinary retention because doxepin HCl has an anticholinergic effect Individuals who have shown previous sensitivity to any of its components

Mode of Action

Potent histamine H1- & H2-receptor antagonist activity.

Precaution

Cautions should be exercised if there is susceptibility to angle-closure glaucoma, urinary retention, severe liver impairment, mania and also in pregnancy and breast-feeding. Drowsiness may affect performance of skilled tasks (e.g. driving) so patient should be careful. Lactation: may pass into breast milk; do not nurse

Side Effect

>10% Burning/stinging (23%),Drowsiness (20%; esp if applied to >10% BSA) 1-10% Dizziness,Dry mouth,Eczema exacerbated,Edema,Fatigue,Mental changes,Pruritus,Taste perversion

Pregnancy Category Note

Pregnancy Category: B Lactation: May pass into breast milk; do not nurse

Interaction

Methylphenidate may increase plasma doxepin levels. Potentially Fatal: Potentiates hypertensive action of sympathomimetics. Increased anticholinergic effects with MAOIs. Additive CNS effects with anticholinergics, CNS depressants and alcohol.

Alternative brand of Doxiderm