Devomit

Devomit25mg+50mg

Type:Tablet

Generic Name:Meclizine Hydrochloride + Pyridoxine Hydrochloride

Manufacturer:Silva Pharmaceuticals Ltd.

Price:3.25

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Indication

Nausea, vomiting, dizziness, motion sickness, radiation sickness and vertigo associated with diseases of vestibular motion sickness, radiation sickness and vertigo associated with diseases of vestibular system, morning sickness during pregnancy, drug induced nausea, vomiting induced by oral contraceptives or Estrogen preparations.

Administration

May be taken with or without food.

Adult Dose

Oral Motion sickness Adult: 25-50 mg Meclizine 1 hr before travelling and repeat 24 hrly if needed. Vertigo and vestibular disorders Adult: 25-100 mg Meclizine daily in divided doses. Discontinue if there is no response after 1-2 wk of treatment. Radiation sickness: 50 mg Meclizine administered 2-12 hours prior to radiation treatment. Pyridoxine (vitamin B6) has been shown to be safe and effective in dosages of 50 to 200 mg per day.

Child Dose

Oral <12 years: Safety and efficacy not established

Contraindication

Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.

Mode of Action

Meclozine blocks vasopressor response to histamine and has a slight blocking action against acetylcholine. It decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways. Pyridoxine is a water-soluble vitamin which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.

Precaution

Prostate hypertrophy, obstruction of bladder neck, narrow angle glaucoma, pyloric stenosis. May impair ability to drive or operate machinery. Pregnancy. Lactation: Not known if excreted in milk; use caution

Side Effect

Drowsiness, thickening of bronchial secretions, dry mouth, fatigue, blurred vision.

Interaction

Additive effects with CNS depressants, neuroleptics, anticholinergics, alcohol.

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