Medicase - Daclin-T - 15gm tube - 1.2gm+.025gm/100gm - Clindamycin Phosphate 1.2% + Tretinoin 0.025% Topical

Daclin-T1.2gm+.025gm/100gm

Type:15gm tube

Generic Name:Clindamycin Phosphate 1.2% + Tretinoin 0.025% Topical

Manufacturer:ACI Limited

Price:৳150.45

Indication

Acne vulgaris

Administration

At first wash the face or affected area gently with warm water or soap. When the skin is completely dried (about 30 minutes later) apply a pea-size amount of gel to your fingertip and spread it over your face.

Adult Dose

Acne Vulgaris Topical Apply a pea-size amount of gel once daily preferably at bed time. Treatment should be continued for 12 weeks.

Child Dose

<12 years old: Safety and efficacy not established >12 years: Apply a pea-size amount of gel once daily preferably at bed time.

Contraindication

Contraindicated in patients with hypersensitivity to clindamycin or tretinoin or any of the ingredients of these medicine.

Mode of Action

Clindamycin: Antibacterial agent that binds to the 50S ribosomal subunits of susceptible bacteria and prevents elongation of peptide chains by interfering with peptidyl transfer, thereby suppressing protein synthesis; reduces surface fatty acids on skin; exact mechanism of action in treating acne unknown Tretinoin: Exact mechanism unknown; appears to cohesiveness of follicular epithelial cells with decrease microcomedo formation; also increases turnover of follicular cells to cause extrusion of comedones

Precaution

Clindacin plus gel is not for oral, ophthalmic, or Intravaginal use. Avoid exposure to sunlight and sunlamps. Wear sunscreen daily. Lactation: excretion in milk unknown; use with caution

Side Effect

>10% Erythema (21-35%),Scaling (13-19%),Itching (15-17%) 1-10% Dryness (6%),Irritation (5%),Exfoliation (5%),Erythema (4%),Pruritus (2%),Stinging (2%),Burning (2%),Sunburn (1%),Dermatitis (1%)

Pregnancy Category Note

Pregnancy Category: C Lactation: excretion in milk unknown; use with caution

Interaction

Clindamycin: May enhance the action of neuromuscular blocking agents (e.g. atracurium). May antagonise the effects of parasympathomimetics. May competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid and chloramphenicol. Increased coagulation tests (prothrombin time/INR) and/or bleeding w/ vit K antagonists (e.g. warfarin, acenocoumarol, fluindione). Tretinoin: Enhances percutaneous absorption of minoxidil. Increased risk of fatal thrombotic complications with antifibrinolytic. Increased tretinoin concentrations with azole antifungals. Enhances peeling action of sulphur, resorcinol, benzoyl peroxide, salicylic acid. Increased photosensitivity with photosensitising medications eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines and sulfonamides. Potentially Fatal: Increased risk of intracranial pressure with tetracyclines.