Cinarzin

Cinarzin15mg

Type:10 Tablets

Generic Name:Cinnarizine

Manufacturer:The Ibn Sina Pharmaceutical Ind. Ltd.

Price:10.00

Ad

Indication

Nausea and vomiting, motion sickness, vertigo, meniere's disease, peripheral vascular diseases, cerebrovascular disorders, vestibular disorders

Administration

Should be taken with food.

Adult Dose

Oral Peripheral vascular disease Adult: 75 mg bid or tid. Motion sickness Adult: 30 mg 2 hr before travel then 15 mg 8 hrly during the journey if necessary. Cerebrovascular disorders Adult: 75 mg once daily. Vertigo and vestibular disorders Adult: 30 mg tid or 75 mg 1-2 times daily.

Child Dose

Oral Motion sickness Child: 5-12 yr 15 mg 2 hr before travel then 7.5 mg 8 hrly during the journey as necessary. Vertigo and vestibular disorders Child: 5-12 yr 15 mg tid.

Contraindication

Proven hypersensitivity to the drug. Parkinson's disease. Childn and neonates.

Mode of Action

Cinnarizine has calcium-channel blocking activity selective for arterial smooth muscle. It also has some antihistamine activity. Cinnarizine acts as a labyrinthine sedative. It also improves microcirculation by reducing ischaemia-induced blood viscosity.

Precaution

Hypotension; pregnancy; lactation; elderly. May impair ability to drive or operate machineries.

Side Effect

Extrapyramidal symptoms sometimes associated with severe depression. Drowsiness, headache, GI upsets, unsteadiness, headache; rarely skin and hypersensitivity reactions, dry mouth, blurred vision, urinary difficulty or retention, constipation and increased gastric reflux, fatigue. Hypolipidaemic effect.

Interaction

CNS depressant effect enhanced with alcohol. Action potentiated by domperidone. Increased sedative effect w/ CNS depressants or TCAs.

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