Type:1gm vial
Generic Name:Cefoperazone
Manufacturer:Drug International Ltd.
Price:৳0.00
Respiratory Tract Infections, Peritonitis and Other Intra-abdominal Infections, Bacterial Septicemia, Infections of the Skin and Skin Structures, Pelvic Inflammatory Disease, Endometritis, and Other Infections of the Female Genital Tract, Urinary Tract Infections
Parenteral Susceptible infections Adult: As sodium: 2-4 g daily in 2 divided doses, increased to 12 g daily in 2-4 divided doses for severe infections given as deep IM or IV infusion. Hepatic impairment: Max for hepatic impairment or biliary obstruction: 4 g daily. W/ renal impairment: 1-2 g daily.
Renal impairment: W/ hepatic impairment: 1-2 g daily.
Hypersensitivity to cephalosporin.
Cefoperazone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
History of penicillin allergy; renal or hepatic impairment; pregnancy, lactation; cystic fibrosis.
Skin rash, urticaria; eosinophilia, diarrhoea, nausea, vomiting; phloebitis; hypoprothrombinaemia; superinfection. Potentially Fatal: Neuromuscular hypersensitivity; nephrotoxicity.
Disulfiram-like reaction with alcohol. Potentiates anticoagulants. Potentially Fatal: Enhances nephrotoxicity by aminoglycosides and furosemide.
