Type:Tablet
Generic Name:Azilsartan Medoxomil
Manufacturer:NIPRO JMI Pharma Limited
Price:৳12.00
Hypertension, alone or in combination w/ other antihypertensive agents.
May be taken with or without food.
Adult: Initially 40 mg once daily. May be increased to a max of 80 mg once daily as necessary. Elderly: No dose adjustment is necessary in elderly patients
Renal Impairment No dose adjustment is required with mild-to-severe renal impairment or end-stage renal disease. Patients with moderate-to-severe renal impairment are more likely to report high serum creatinine values.
Hypersensitivity. Pregnancy.
Angiotensin II blocker; displaces angiotensin II from AT1 receptor and may lower blood pressure by antagonizing AT1-induced vasoconstriction, aldosterone release, catecholamine release, arginine vasopressin release, water absorption, and hypertrophic responses. May induce more complete inhibition of renin-angiotensin system compared with ACE inhibitors; does not affect response to bradykinin. Inhibits the pressor effects of an angiotensin II infusion in a dose-related manner.
Correct vol or salt depletion prior to administration. Renal (moderate to severe) & hepatic (severe) impairment. Pregnancy (1st trimester) & lactation. Childn <18 yr. Monitor serum K in patients taking K-sparing diuretics, salt substitutes containing K & drugs that increase K levels (eg heparin) & creatinine levels in patients w/ renal impairment & type 2 DM. Aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy. Lactation: unknown whether distributed in breast milk, decide on alternate antihypertensive therapy or do not breastfeed
1-10% Diarrhea (2%) <1% Nausea,Asthenia,Fatigue,Muscle spasm,Dizziness,Postural hypotension,Cough
Pregnancy Category: C (1st trimester); D (2nd and 3rd trimesters)
Reversibly increases serum conc & toxicity of lithium; attenuated antihypertensive effects & risk of worsening of renal function may occur w/ NSAIDs. Hyperkalemia w/ K-sparing diuretics & K supplements.
