Type:10 Tablets
Generic Name:Prasugrel
Manufacturer:Unimed Unihealth Pharmaceuticals Ltd.
Price:৳140.00
Acute coronary syndromes, thrombotic cardiovascular (CV) events, stent thrombosis, unstable angina (UA), non-ST-elevation myocardial infarction (NSTEMI), ST-elevation myocardial infarction (STEMI), Stroke
May be taken with or without food.
Oral Acute coronary syndrome Adult: 60 mg as loading dose, followed by 10 mg once daily for up to 12 mth, given in combination w/ aspirin. Elderly: >75 yr Maintenance: 5 mg once daily. Patient w/ low body wt (<60 kg): 5 mg once daily as maintenance dose. Hepatic impairment: Severe (Child-Pugh class C): Contraindicated.
Renal impairment Dose adjustment not necessary
Active pathological bleeding such as peptic ulcer or intracranial hamorrhage. Patient with a history of prior transient ischemic attack or stroke
Prasugrel is a prodrug that inhibits platelet activation and aggregation. The active metabolite irreversibly blocks the P2Y12 component of adenosine diphosphate (ADP) receptors on the platelet, which prevents activation of the GPIIb/IIIa receptor complex, thereby reducing platelet activation and aggregation.
Patient w/ propensity to bleed, low body wt (<60 kg). Patient who will undergo CABG and other surgical procedure; coronary angiography in UA/NSTEMI patients. Elderly (>75 yr). Pregnancy and lactation. Monitoring Parameters Monitor Hb and haematocrit periodically; may consider platelet function testing.
1-10% Bleeding,Anemia,Atrial fibrillation,Back pain,Bradycardia,Dizziness,Dyspnea,Headache,Hypertension,Nausea <1% Thrombotic thrombocytopenic purpura,Abnormal hepatic function,Angioedema,Hematoma,Hemolysis,Hemorrhage,Abnormal liver function
Increased risk of bleeding w/ oral anticoagulants (e.g. warfain), clopidogrel, NSAIDs and fibrinolytics.
