Alvastin

Alvastin10mg

Type:Tablet

Generic Name:Ebastine

Manufacturer:Incepta Pharmaceuticals Ltd.

Price:0.00

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Indication

Allergic rhinitis, Allergic conditions, Chronic idiopathic urticaria

Administration

May be taken with or without food.

Adult Dose

Oral Allergic conditions Adult: 10-20 mg once daily.

Child Dose

Oral Allergic conditions Child: >6 yr: 5 mg once daily.

Contraindication

Hypersensitivity, cardiac arrhythmias.

Mode of Action

Ebastine, a piperidine derivative, is a long-acting, nonsedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It is metabolised to active metabolite, carebastine. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.

Precaution

Caution is advised when used in hepatic impairment, renal insufficiency, QTc interval prolongation. Pregnancy, lactation.

Side Effect

Headache, dry mouth, drowsiness, pharyngitis, abdominal pain, dyspepsia, asthenia, epistaxis, rhinitis, sinusitis, nausea, insomnia.

Interaction

Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation.

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